Aflatoxin B1 disrupts the androgen biosynthetic pathway in rat Leydig cells.

  title={Aflatoxin B1 disrupts the androgen biosynthetic pathway in rat Leydig cells.},
  author={Isaac Adegboyega Adedara and Manjunatha K Nanjappa and E O Farombi and B T Akingbemi},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
The present study investigated if Aflatoxin B1 (AFB1), a potent and naturally occurring mycotoxin, interferes with the steroidogenic pathway in rat Leydig cells. Testicular Leydig cells are the predominant source of the male sex steroid hormone testosterone (T) that maintains the male phenotype and support fertility. Leydig cells, isolated from 35-day-old male Long-Evans rats (Rattus norvegicus), were incubated with AFB1 at 0, 0.01, 0.1, 1, 10μM followed by measurement of T secretion by… CONTINUE READING
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