Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas

  • Daniel R.McFarlin, Mary J.Lindstrom, Michael N.Gould
  • Published 2003


The role of three major Ras downstream effector pathways in the induction of mammary cancer was studied using an in situ mammary ductal gene delivery model. Replicationdefective retroviral vectors were used to infect endogenous rat mammary epithelial cells with three individual Ras effector loop mutants, each of which transduces its signal through a… (More)


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