Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas.

@article{McFarlin2003AffinityWR,
  title={Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas.},
  author={Daniel R. McFarlin and Mary J. Lindstrom and Michael N. Gould},
  journal={Carcinogenesis},
  year={2003},
  volume={24 1},
  pages={99-105}
}
The role of three major Ras downstream effector pathways in the induction of mammary cancer was studied using an in situ mammary ductal gene delivery model. Replication-defective retroviral vectors were used to infect endogenous rat mammary epithelial cells with three individual Ras effector loop mutants, each of which transduces its signal through a different Ras effector pathway (Raf, PI3K or RalGDS). Several groups have used Ras effector loop mutants in cultured cells, clearly characterizing… CONTINUE READING