Affinity purification of IgG subclasses and the distribution of thyroid auto-antibody reactivity in Hashimoto's thyroiditis.

@article{Weetman1989AffinityPO,
  title={Affinity purification of IgG subclasses and the distribution of thyroid auto-antibody reactivity in Hashimoto's thyroiditis.},
  author={Anthony P. Weetman and C. Black and Sara Bar Cohen and Richard Tomlinson and J. P. Banga and Cecile Reimer},
  journal={Scandinavian journal of immunology},
  year={1989},
  volume={30 1},
  pages={73-82}
}
To delineate accurately the IgG subclass distribution of thyroid auto-antibodies, sera from nine patients with Hashimoto's thyroiditis were fractionated into IgG subclasses by complete depletion of the other IgG subclasses on affinity columns. All IgG subclass fractions contained thyroglobulin and microsomal (or thyroid peroxidase) antibody activity, although when compared to the total serum concentrations of IgG subclasses, IgG4 antibodies were overrepresented. However, in contrast to recent… CONTINUE READING
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