Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets.


BACKGROUND P-selectin is an adhesion receptor expressed on activated platelets and endothelial cells. Its natural ligand, P-selectin glycoprotein ligand-1, is expressed on leucocytes and the P-selectin/PSGL-1 interaction is involved in leukocyte rolling. We have compared the interaction of P-selectin with several low molecular weight polysaccharides… (More)
DOI: 10.1016/j.bbagen.2008.10.008


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