Affinity of cephalosporins for beta-lactamases as a factor in antibacterial efficacy.

  title={Affinity of cephalosporins for beta-lactamases as a factor in antibacterial efficacy.},
  author={D W Phelps and D D Carlton and Craig A. Farrell and R. E. Kessler},
  journal={Antimicrobial agents and chemotherapy},
  volume={29 5},
Strains of Escherichia coli, Enterobacter aerogenes, and Enterobacter cloacae that were resistant to ceftazidime (MIC greater than 16 micrograms/ml) but susceptible to BMY 28142 (MIC less than 4 micrograms/ml) were found to contain higher levels of beta-lactamase activity (50- to 3,340-fold) than control strains of the corresponding species. Ceftazidime was at least as resistant as BMY 28142 to hydrolysis by these enzymes. However, the apparent Ki of BMY 28142 for each enzyme was larger (8- to… CONTINUE READING

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