Affinity of 1,2-substituted oxytocin analogues to the uterus receptor: Free-Wilson and Hansch analysis

Abstract

The analysis of pA2 values for 1,2-substituted oxytocin analogues suggests a significant resonance effect of psubstituted groups in 2-tyrosine when the hormone binds to its uterus receptor, whereas the N-terminal amino group exerts less clearly characterized effects (participation of its lipophilicity and molecular volume can be assumed). 
DOI: 10.1007/BF01922951

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