Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.


Helper T-cell activation generally requires the coreceptor CD4, which binds MHC class II molecules. A remarkable feature of the CD4-MHC class II interaction is its exceptionally low affinity, which ranges from K(D) = ∼200 μM to >2 mM. Investigating the biological role of the much lower affinity of this interaction than those of other cell-cell recognition… (More)
DOI: 10.1073/pnas.1109438108


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