Affinity maturation and functional dissection of a humanised anti-RAGE monoclonal antibody by ribosome display.

@article{Hufton2012AffinityMA,
  title={Affinity maturation and functional dissection of a humanised anti-RAGE monoclonal antibody by ribosome display.},
  author={Simon E Hufton},
  journal={Methods in molecular biology},
  year={2012},
  volume={805},
  pages={403-22}
}
The pursuit of more potent, safe, and cost-effective drugs has placed a greater emphasis on antibody optimisation within the drug discovery process. Technologies to rapidly improve antibody drug performance, such as phage display, ribosome display, and yeast display, are playing a key role in this effort. Among these ribosome display is a particularly powerful technology and has recently been applied to the affinity optimisation of a humanised anti-receptor for advanced glycation end products… CONTINUE READING