Affinity ligands for glycoprotein purification based on the multi-component Ugi reaction.


One challenge facing the purification of therapeutic glycoproteins by affinity chromatography is creating ligands specific for the glycan moiety. Affinity chromatography of glycoproteins is currently conducted with immobilized lectins or boronates, although biomimetic ligands could present a more desirable option. This work describes the rational design and… (More)
DOI: 10.1016/j.jchromb.2014.07.035


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