Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock.

  • Warren H. Meck
  • Published 1986 in Pharmacology, biochemistry, and behavior

Abstract

For each of five neuroleptics (chlorpromazine, haloperidol, pimozide, promazine, and spiroperidol), the dose required to produce a rightward horizontal shift of 15-20% for psychophysical bisection functions that relate the percentage of long responses to signal duration was determined in rats for two different signal ranges (2-8 sec and 4-16 sec). Affinity… (More)

Topics

Cite this paper

@article{Meck1986AffinityFT, title={Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock.}, author={Warren H. Meck}, journal={Pharmacology, biochemistry, and behavior}, year={1986}, volume={25 6}, pages={1185-9} }