Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration.

Abstract

Glial-derived neurotrophic factor (GDNF) promotes both sensory and motor neuron survival. The delivery of GDNF to the peripheral nervous system has been shown to enhance regeneration following injury. In this study, we evaluated the effect of affinity-based delivery of GDNF from a fibrin matrix in a nerve guidance conduit on nerve regeneration in a 13 mm… (More)
DOI: 10.1016/j.actbio.2008.11.008

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Cite this paper

@article{Wood2009AffinitybasedRO, title={Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration.}, author={Matthew D Wood and Amy Marie Moore and Daniel Hunter and Sami H. Tuffaha and Gregory H. Borschel and Susan E. Mackinnon and Shelly Sakiyama-Elbert}, journal={Acta biomaterialia}, year={2009}, volume={5 4}, pages={959-68} }