Affinity Labeling of Rat Glutathione S-Transferase Isozyme 1-1 by 17β-Iodoacetoxy-estradiol-3-sulfate*

@article{Vargo2001AffinityLO,
  title={Affinity Labeling of Rat Glutathione S-Transferase Isozyme 1-1 by 17$\beta$-Iodoacetoxy-estradiol-3-sulfate*},
  author={M. Vargo and R. Colman},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={2031 - 2036}
}
  • M. Vargo, R. Colman
  • Published 2001
  • Medicine, Chemistry
  • The Journal of Biological Chemistry
Rat liver glutathione S-transferase, isozyme 1-1, catalyzes the glutathione-dependent isomerization of Δ5-androstene-3,17-dione and also binds steroid sulfates at a nonsubstrate inhibitory steroid site. 17β-Iodoacetoxy-estradiol-3-sulfate, a reactive steroid analogue, produces a time-dependent inactivation of this glutathioneS-transferase to a limit of 60% residual activity. The rate constant for inactivation (k obs) exhibits a nonlinear dependence on reagent concentration withK I = 71 μm andk… Expand
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