Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays.

@article{Teif2015AffinitySA,
  title={Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays.},
  author={V. B. Teif and Nick Kepper and K. Yserentant and G. Wedemann and K. Rippe},
  journal={Journal of physics. Condensed matter : an Institute of Physics journal},
  year={2015},
  volume={27 6},
  pages={
          064110
        }
}
  • V. B. Teif, Nick Kepper, +2 authors K. Rippe
  • Published 2015
  • Physics, Medicine, Biology
  • Journal of physics. Condensed matter : an Institute of Physics journal
  • Heterochromatin protein 1 (HP1) participates in establishing and maintaining heterochromatin via its histone-modification-dependent chromatin interactions. In recent papers HP1 binding to nucleosomal arrays was measured in vitro and interpreted in terms of nearest-neighbour cooperative binding. This mode of chromatin interaction could lead to the spreading of HP1 along the nucleosome chain. Here, we reanalysed previous data by representing the nucleosome chain as a 1D binding lattice and showed… CONTINUE READING
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