Affinities of Brompheniramine, Chlorpheniramine, and Terfenadine at the Five Human Muscarinic Cholinergic Receptor Subtypes

@article{Yasuda1999AffinitiesOB,
  title={Affinities of Brompheniramine, Chlorpheniramine, and Terfenadine at the Five Human Muscarinic Cholinergic Receptor Subtypes},
  author={Sally Usdin Yasuda and Robert P. Yasuda},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1999},
  volume={19}
}
  • S. Yasuda, R. Yasuda
  • Published 1 April 1999
  • Biology, Chemistry
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Anticholinergic effects are presumed to be the mechanism for the efficacy of chlorpheniramine in symptomatic relief of the common cold. Terfenadine, a second‐generation antihistamine, reportedly lacks anticholinergic side effects. We evaluated affinities of two commonly used over‐the‐counter antihistamines, brompheniramine and chlorpheniramine, as well as terfenadine in comparison with atropine at the five human muscarinic cholinergic receptor subtypes using CHO cells stably transfected with… 
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