Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data

@article{Ojasoo1994AffiliationsAS,
  title={Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data},
  author={Tiiu Ojasoo and Jean Pierre Raynaud and John C. Dore},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1994},
  volume={48},
  pages={31-46}
}
To illustrate the informative value of descriptive multivariate analysis in biochemical screening, we have analyzed several data matrices relating to the binding of steroids to the estrogen, progestin, androgen, glucocorticoid and mineralocorticoid receptors in different organs and species. We first compared dendrograms of steroid hormone receptors, that were obtained by an automatic hierarchical classification analysis of the binding data, to published phylogenetic trees of nuclear receptors… Expand
View on Elsevier
doi.org
14 Citations
Background Citations
1

14 Citations

Citation Type

Citation Type

Correspondence factor analysis of steroid libraries
TLDR
The receptor binding of a library of 187 steroids to five steroid hormone receptors has been analyzed by correspondence factor analysis in order to illustrate how the method could be used to derive structure-activity-relationships from much larger libraries. Expand
Taxonomy of nuclear receptors and SERPINS by multivariate analysis of amino-acid composition
  • T. Ojasoo, J. Dore
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 1996
The global amino-acid composition of a protein, although a cruder variable than sequence, is nevertheless informative and has been correlated with protein structural class. In the present study, we… Expand
Structure and function of the glucocorticoid receptor ligand binding domain.
TLDR
The purpose of this review is to discuss the many structural and functional features of the GR LBD in light of recent successful biochemical and crystallographic studies. Expand
The ligand insertion hypothesis in the genomic action of steroid hormones 1 1 Proceedings of the 13th International Symposium of the Journal of Steroid Biochemistry & Molecular Biology “Recent Advances in Steroid Biochemistry & Molecular Biology” Monaco 25–28 May 1997.
TLDR
The feasibility of insertion was investigated using computer models of the glucocorticoid receptor DNA binding domain bound to its HRE, and cortisol formed hydrogen bonds to both the receptor and DNA. Expand
Role of the Androgen Receptor in Human Breast Cancer
TLDR
The presence of structurally altered AR in breast cancers may account for unresponsiveness to MPA treatment following failure of tamoxifen therapy, and identification of androgen-regulated genes may lead to new possibilities for the hormonal treatment of breast cancer. Expand
Dissociation of 4-hydroxytamoxifen, but not estradiol or tamoxifen aziridine, from the estrogen receptor as the receptor binds estrogen response element DNA
TLDR
Results confirm that one molecule of 4-OHT ligand dissociates from the ER dimer apparently during the process of binding to DNA, and are likely to induce a conformation in ER dimers that alters their capacity for gene activation. Expand
Estrogen and Progestin Bioactivity of Foods, Herbs, and Spices
  • D. Zava, C. Dollbaum, M. Blen
  • Medicine, Biology
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1998
TLDR
It is demonstrated that many of the commonly consumed foods, herbs, and spices contain phytoestrogens and phytoprogestins that act as agonists and antagonists in Vivo. Expand
Mining and Visualizing Large Anticancer Drug Discovery Databases
TLDR
Mining the database of screened compounds in vitro for the development of anticancer drugs, for a better understanding of the molecular pharmacology of cancer, and for improvement of the drug discovery process can provide useful information. Expand
CHAPTER 10 – Adrenal Corticoid
A morphologist's approach to the vagina--age-related changes and estrogen sensitivity.
TLDR
Differences in estrogen sensitivity between uterus and vagina are discussed as well as the background for the high vaginal sensitivity. Expand
...
1
2
...

References

SHOWING 1-10 OF 42 REFERENCES
Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis.
TLDR
The analysis has confirmed previous correlations between GR binding and TAT response but also highlighted the antiglucocorticoid activity of progestins and should prove to be a substantial aid to the interpretation of increasingly complex data. Expand
Correspondence analysis applied to steroid receptor binding.
The relative binding affinities of 48 steroids for four classes of hormone receptor (progestin, PR; androgen, AR; glucocorticoid, GR; mineralocorticoid, MR) have been analyzed by correspondence… Expand
Unique steroid congeners for receptor studies.
TLDR
In this study, a simple in vitro system used to define the molecular requirements for a highly specific interaction between a steroid and the receptor corresponding to a single class of hormone is described. Expand
Estrogen receptor stereochemistry: ligand binding and hormonal responsiveness
TLDR
These compounds should be useful probes for studying the individual responses involved in estrogen-induced uterine growth, and are shown to have a stereochemical chiral preference for the IA isomer but not IB. Expand
Evolution of the nuclear receptor gene superfamily.
TLDR
A complex evolutionary history for nuclear receptor genes in which gene duplication events and swapping between domains of different origins took place is suggested. Expand
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
TLDR
The response profiles of 36 para-substituted diphenylethylenes and triphenylacrylonitriles have been compared by multivariate analysis and it is confirmed that cytotoxicity is much more clearly correlated with inhibition of diacylglycerol-stimulated PKC activity than with RBAs for ER. Expand
Steroid flexibility and receptor specificity.
TLDR
It is suggested that the lock-and-key image of complex formation is too static and that the overall steroid-cum-protein flexibility determines complex kinetics and biological response. Expand
Relative involvement of protein kinase C and of the estrogen receptor in the cytotoxic action of a population of triphenylethylenes on MCF7 cells as revealed by correspondence factorial (CF) analysis
TLDR
Results suggest that MCF7 cells might be most sensitive to a cytotoxic effect of TPEs (via PKC and other targets) when they at the same time decrease estrogen-stimulated proliferation via an ER-mediated antiestrogenic effect. Expand
Oestriol receptor interactions: their biological importance and therapeutic implications.
TLDR
Overall the specificity of receptors to various target tissues including human breast cancer and myometrial tissue rat myometrium and rabbitMyometrium pituitary and thymus was very similar making preferential binding of estriol to specific estrogen receptors unlikely. Expand
A variant estrogen receptor messenger ribonucleic acid is associated with reduced levels of estrogen binding in human mammary tumors.
TLDR
A significant correlation was found between the ER mRNA levels and the estrogen binding concentrations determined by a dextran-coated charcoal assay, which suggests that the observed B variant might lead to the production of receptors with altered properties. Expand
...
1
2
3
4
5
...