Affibody molecules for in vivo characterization of HER2-positive tumors by near-infrared imaging.

@article{Lee2008AffibodyMF,
  title={Affibody molecules for in vivo characterization of HER2-positive tumors by near-infrared imaging.},
  author={Sang Bong Lee and Moinuddin Hassan and Robert P Fisher and Oleg Y. Chertov and Victor Chernomordik and Gabriela Kramer-Marek and Amir Gandjbakhche and Jacek Capala},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 12},
  pages={3840-9}
}
PURPOSE HER2 overexpression has been associated with a poor prognosis and resistance to therapy in breast cancer patients. We are developing molecular probes for in vivo quantitative imaging of HER2 receptors using near-infrared (NIR) optical imaging. The goal is to provide probes that will minimally interfere with the studied system, that is, whose binding does not interfere with the binding of the therapeutic agents and whose effect on the target cells is minimal. EXPERIMENTAL DESIGN We… CONTINUE READING

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Radionu - clide therapy of HER 2 - positive microxenografts using a 177 Lu - labeled HER 2 - specific Affibody molecule

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