Affibody Molecules in Biotechnological and Medical Applications.

  title={Affibody Molecules in Biotechnological and Medical Applications.},
  author={Stefan St{\aa}hl and Torbj{\"o}rn Gr{\"a}slund and Amelie Eriksson Karlstr{\"o}m and Fredrik Y. Frejd and Per-{\AA}ke Nygren and John L{\"o}fblom},
  journal={Trends in biotechnology},
  volume={35 8},
Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle domain framework. Since their introduction 20 years ago as an alternative to antibodies for biotechnological applications, the first therapeutic affibody molecules have now entered clinical development and more than 400 studies have been published in which affibody molecules have been developed and used in a variety of contexts. In this review, we focus primarily on efforts over the past 5 years to explore… CONTINUE READING
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