Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans.

@article{Huffnagle1996AfferentPP,
  title={Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans.},
  author={Gary B Huffnagle and Galen B. Toews and Marie D. Burdick and Michael Boyd and Katherine McAllister and Roderick A. McDonald and Steven L. Kunkel and Robert M. Strieter},
  journal={Journal of immunology},
  year={1996},
  volume={157 10},
  pages={4529-36}
}
The development of T cell immunity is required to clear a pulmonary Cryptococcus neoformans infection (via the recruitment and activation of inflammatory cells). The objective of our studies was to determine whether TNF-alpha is required during the afferent phase of the response. The levels of TNF-alpha mRNA and protein in the lungs increased following intratracheal inoculation of CBA/J mice with C. neoformans 52 and preceded the development of an inflammatory response in the lungs… CONTINUE READING

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