Afferent nerve-mediated protection against deep mucosal damage in the rat stomach.

  title={Afferent nerve-mediated protection against deep mucosal damage in the rat stomach.},
  author={Peter Holzer and Maria Anna Pabst and Irmgard Th. Lippe and Brigitta M. Peskar and Bernhard A. Peskar and Edward H. Livingston and Paul H. Guth},
  volume={98 4},
Intragastric capsaicin protects against ethanol-induced gross mucosal lesion formation by stimulation of afferent nerve endings in the rat stomach. The aims of the present study were to examine histologically the protective effect of capsaicin and to test whether this effect is related to changes in mucosal eicosanoid formation and mucosal blood flow. Intragastric capsaicin (160 microM) significantly reduced gross mucosal lesion formation induced by 25% ethanol. Light microscopy revealed that… CONTINUE READING


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