Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism.

@article{Keating2008AfferentHI,
  title={Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism.},
  author={Christopher J Keating and Michael J. Beyak and Stephen F. Foley and Gulzar Singh and Charles Marsden and Robin Spiller and David Grundy},
  journal={The Journal of physiology},
  year={2008},
  volume={586 18},
  pages={4517-30}
}
Visceral hypersensitivity is an important clinical feature associated with irritable bowel syndrome which in some patients has been linked to prior infection. Here we employ an animal model in which transient infection leads to persistent gut dysfunction to investigate the role of altered 5-HT metabolism upon afferent mechanosensensitivity in the post-infected gut. Jejunal segments isolated from Trichinella spiralis-infected mice were used to assess 5-HT metabolism whilst afferent activity in T… CONTINUE READING

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