Affected sib-pair methods for detecting linkage to dichotomous traits: review of the methodology.

Abstract

Affected sib-pair methods are commonly used to detect linkage to dichotomous traits. This review discusses the principles underlying affected sib-pair tests for linkage and the merits of sib-pair methods relative to traditional lod score methods. Extensions of the methods to include other typed unaffected relatives, extra affected siblings, and multiple… (More)

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Cite this paper

@article{Holmans1998AffectedSM, title={Affected sib-pair methods for detecting linkage to dichotomous traits: review of the methodology.}, author={Peter Holmans}, journal={Human biology}, year={1998}, volume={70 6}, pages={1025-40} }