Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

@article{DeteraWadleigh1996AffectedsibpairAR,
  title={Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.},
  author={S. D. Detera-Wadleigh and Judith A. Badner and Lynn R Goldin and Wade H. Berrettini and Alan R. Sanders and Dorothy Rollins and Gillian Turner and Tracy Y. Moses and Hafez Haerian and David S. Muniec and John J I Nurnberger and Elliot S. Gershon},
  journal={American journal of human genetics},
  year={1996},
  volume={58 6},
  pages={1279-85}
}
In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and… CONTINUE READING

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