Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A

@inproceedings{Chao2015AfatinibIA,
  title={Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A},
  author={Ting-Ting Chao and Cheng-Yi Wang and Yen-Lin Chen and Chih-Chen Lai and Fang-Yu Chang and Yi-Ting Tsai and Chung-Hao H. Chao and C S Shiau and Y. T. Huang and Chong-Jen Yu and Kuen-Feng Chen},
  booktitle={Oncotarget},
  year={2015}
}
Afatinib has anti-tumor effect in non-small cell lung carcinoma (NSCLC) with epidermal growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in NSCLC cells without EGFR mutation through CIP2A pathway. Four NSCLC cell lines (H358 H441 H460 and A549) were treated with afatinib to determine their sensitivity to afatinib-induced… CONTINUE READING