Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.

@article{Bttner2010Af9Mllt3IW,
  title={Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.},
  author={Nicole B{\"u}ttner and Steven A Johnsen and Sebastian K{\"u}gler and Tanja Vogel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 15},
  pages={7042-7}
}
Mutations of leukemia-associated AF9/MLLT3 are implicated in neurodevelopmental diseases, such as epilepsy and ataxia, but little is known about how AF9 influences brain development and function. Analyses of mouse mutants revealed that during cortical development, AF9 is involved in the maintenance of TBR2-positive progenitors (intermediate precursor cells, IPCs) in the subventricular zone and prevents premature cell cycle exit of IPCs. Furthermore, in postmitotic neurons of the developing… CONTINUE READING
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