Aetiology of thyroidal dysfunction in murine toxoplasmosis.

@article{Stahl1998AetiologyOT,
  title={Aetiology of thyroidal dysfunction in murine toxoplasmosis.},
  author={Walter Stahl and Yoshimasa Kaneda},
  journal={Parasitology},
  year={1998},
  volume={117 ( Pt 3)},
  pages={223-7}
}
Mice infected with Toxoplasma gondii manifest a rapid decline in serum thyroxine (T4) levels. To locate the locus of the hypothyroxinaemia, the integrity of the pituitary-thyroid axis of infected mice was assessed by a thyrotropin-releasing hormone (TRH) assay. A rise in serum T4 after inoculation of TRH implies the release of thyrotropin (thyroid-stimulating hormone) from a functionally intact pituitary. Administration of a single, large-dose (1 microgram) bolus of TRH to infected mice induced… CONTINUE READING