Aetiology of childhood acute leukaemias: current status of knowledge.

  title={Aetiology of childhood acute leukaemias: current status of knowledge.},
  author={Claudia Rossig and Heribert J{\"u}rgens},
  journal={Radiation protection dosimetry},
  volume={132 2},
Acute leukaemia is a consequence of malignant transformation of a haematopoetic progenitor cell. Molecular studies have revealed a prenatal origin of many childhood leukaemias. According to current models, a preleukaemic stem cell clone is generated by a first mutation in utero which, in a minority of children, progresses to leukaemia after receiving further postnatal genetic hits. The nature of pre- and postnatal events involved in leukaemogenesis in children is not well understood. Although… CONTINUE READING
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