Aetiological heterogeneity of head and neck squamous cell carcinomas: the role of human papillomavirus infections, smoking and alcohol.

@article{Farsi2017AetiologicalHO,
  title={Aetiological heterogeneity of head and neck squamous cell carcinomas: the role of human papillomavirus infections, smoking and alcohol.},
  author={Nada J. Farsi and Mf. Rousseau and Nicolas F Schlecht and Genevi{\`e}ve Castonguay and Paul Allison and Phuc Felix Nguyen-Tan and Denis Souli{\'e}res and François Coutl{\'e}e and Michael Peter Hier and Sreenath Arekunnath Madathil and Eduardo L Franco and Belinda Nicolau},
  journal={Carcinogenesis},
  year={2017},
  volume={38 12},
  pages={
          1188-1195
        }
}
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol and HPV infection on OPC risk in the head and neck cancer (HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers… CONTINUE READING
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