Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".

@article{Plaza2012AetheramidesAA,
  title={Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".},
  author={Alberto Plaza and Ronald O Garcia and Giuseppe Bifulco and Javier Pablo Martinez and Stephan H{\"u}ttel and Florenz Sasse and Andreas Meyerhans and Marc Stadler and Rolf M{\"u}ller},
  journal={Organic letters},
  year={2012},
  volume={14 11},
  pages={
          2854-7
        }
}
Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter". The structures were solved by a combination of NMR analyses, quantum mechanical calculations, and chemical derivatizations. Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 μM. Furthermore aetheramides showed cytostatic activity against human colon carcinoma (HCT… Expand

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