Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity.

@article{Kong2002AesculinPP,
  title={Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity.},
  author={Lingdong Kong and Jin Zhou and Yaolin Wen and Jianmei Li and Christopher Hon Ki Cheng},
  journal={Planta medica},
  year={2002},
  volume={68 2},
  pages={175-8}
}
The natural product aesculin was demonstrated to possess potent hypouricemic effects in in vivo models of hyperuricemia in both mice and rats pretreated with oxonate. Aesculin, when administered intraperitoneally to the oxonate-induced hyperuricemic rodents, was able to elicit dose-dependent hypouricemic effects. At doses of 150 mg/kg of aesculin or above, the serum urate levels of the oxonate-pretreated mice were not different from normal mice. Such an effect in mice was observed as quick as 1… CONTINUE READING

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