Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema.

@article{Cantor2005AerosolizedHL,
  title={Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema.},
  author={Jerome Cantor and Joseph M. Cerreta and Marcos Ochoa and Shuren Ma and Tony K F Chow and Gabriele Grunig and Gerard M. Turino},
  journal={Experimental lung research},
  year={2005},
  volume={31 4},
  pages={417-30}
}
This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated/smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 microm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous… CONTINUE READING

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