Aerosolized endotoxin is immediately bound by pulmonary surfactant protein D in vivo.

@article{Rozendaal1999AerosolizedEI,
  title={Aerosolized endotoxin is immediately bound by pulmonary surfactant protein D in vivo.},
  author={B. A. van Rozendaal and C. V. D. van de Lest and M. van Eijk and L. M. V. van Golde and W. Voorhout and H. V. van Helden and H. Haagsman},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1454 3},
  pages={
          261-9
        }
}
Collectins are carbohydrate binding proteins that are implicated in innate host defense. The lung collectins, surfactant proteins A and D (SP-A and SP-D), bind a variety of pathogens in vitro and influence phagocytosis by alveolar macrophages. In this report we show that SP-D binds endotoxin (lipopolysaccharide, LPS) in vivo in a rat model of acute respiratory distress syndrome (ARDS). Intratracheal aerosolization of LPS in rats resulted in the typical features of human ARDS. Total amounts of… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Surfactant proteins A and D increase in response to intratracheal lipopolysaccharide.
TLDR
Data are consistent with the hypothesis that SP-A and SP-D are upregulated by an acute inflammatory stress in a manner analogous to that of the structurally and functionally related serum acute-phase reactant, mannose-binding protein. Expand
Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.
TLDR
The results suggest that SP-D--alone, and in conjunction with SP-A and phagocytic cells--constitutes an important component of the natural immune response to IAV infection within the respiratory tract. Expand
Lectin-mediated interactions of surfactant protein D with alveolar macrophages.
TLDR
Specific saccharide-mediated interactions of SP-D with alveolar macrophages in lung tissue and in vitro are described and it is speculated that the multivalent structure ofSP-D mediates bridging interactions between microbial glycoconjugates or surfactant phospholipids and specific glycosylated ligands expressed on the surface of phagocytic cells. Expand
Surfactant protein D. Increased accumulation in silica-induced pulmonary lipoproteinosis.
TLDR
The studies indicate that the extracellular accumulation of SP-D is markedly increased in silica-induced lipoproteinosis, and that SP- D is associated with amorphous components identified by electron microscopy. Expand
Opsonic activities of surfactant proteins A and D in phagocytosis of gram-negative bacteria by alveolar macrophages.
TLDR
In flow cytometric studies with fluorescein-labeled rough (J5) and smooth (O111) Escherichia coli and rat alveolar macrophages, SP-A enhanced binding of J5 but not O111 bacteria to macrophage and subsequent bacterial killing. Expand
Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage.
TLDR
It is suggested that SP-D plays important roles in the lung's defense against Gram-negative bacteria. Expand
Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome.
TLDR
It is suggested that intratracheal LPS administration mimics the clinical development of ARDS very closely. Expand
Surfactant protein D binding to alveolar macrophages.
TLDR
It is concluded that SP-D binds specifically to alveolar macrophages and the receptor involved is different from that utilized by C1q. Expand
Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages.
TLDR
The interaction of SP-D with gpA represents an additional important component of the host-parasite relationship during P. carinii pneumonia and augments binding of P.Carinii to alveolar macrophages, but does not significantly enhance macrophage phagocytosis of the organism. Expand
Potential role of surfactant proteins A and D in innate lung defense against pathogens.
The physiological role of pulmonary surfactant is probably not limited to conferring mechanical stability to the alveoli. Increasing evidence suggests that surfactant components, in particular theExpand
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