Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse.

@article{Renz1992AerosolizedAE,
  title={Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse.},
  author={Harald Renz and Howard R. Smith and Jaimee Henson and Bronson S. Ray and Charles G. Irvin and ErwinW. Gelfand},
  journal={The Journal of allergy and clinical immunology},
  year={1992},
  volume={89 6},
  pages={
          1127-38
        }
}
Inhalation of an antigen, ovalbumin (OVA), in the absence of adjuvant has been demonstrated to induce an immune response that is associated with increased airway responsiveness. Determination of OVA-specific serum IgE and IgG antibody responses revealed an early increase in antibody titers that were initially restricted to the IgE class. Subsequently, IgG antibody titers increased and IgE antibody plateaued. Furthermore, we observed a tenfold increase in the number of lymphocytes caused by a… CONTINUE READING
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