Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.

@article{Vogelmeier1990AerosolizationOR,
  title={Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.},
  author={Claus F Vogelmeier and R. Buhl and Richard F. Hoyt and Elizabeth M. Wilson and Gerald A. Fells and Richard C. Hubbard and Hans Peter Schnebli and Robert A. Thompson and Ronald G. Crystal},
  journal={Journal of applied physiology},
  year={1990},
  volume={69 5},
  pages={1843-8}
}
In a variety of lung diseases the respiratory epithelial surface must contend with an increased burden of neutrophil elastase (NE). One candidate for augmenting epithelial anti-NE protection is the secretory leukoprotease inhibitor (SLPI). In vitro evaluation demonstrated that 96 +/- 1% of the recombinant SLPI (rSLPI) molecules were capable of inhibiting NE, with an association rate constant of 7.1 +/- 0.1 X 10(6) M-1.s-1. Evaluation of rSLPI after in vitro and in vivo aerosolization showed… CONTINUE READING
22 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…