Aerosol infection of cynomolgus macaques with enzootic strains of venezuelan equine encephalitis viruses.

@article{Reed2004AerosolIO,
  title={Aerosol infection of cynomolgus macaques with enzootic strains of venezuelan equine encephalitis viruses.},
  author={Douglas Reed and Cathleen M. Lind and Lawrence J Sullivan and William D. Pratt and Michael D. Parker},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 6},
  pages={1013-7}
}
Because Venezuelan equine encephalitis viruses (VEEVs) are infectious by aerosol, they are considered to be a biological-weapons threat. Nonhuman-primate models are needed to evaluate the efficacy of candidate vaccines. In the present study, cynomolgus macaques, after aerosol exposure to either VEEV-IE or VEEV-IIIA, developed fever, viremia, and lymphopenia; the severity of the fever response, viremia, and lymphopenia correlated with the inhaled dose of VEEV. Of the 10 macaques in our study, 7… CONTINUE READING