Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats.

@article{Budts2000AerosolGT,
  title={Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats.},
  author={Werner Budts and Peter Pokreisz and Z Nong and Natascha Van Pelt and Hilde Gillijns and Rutger Gerard and R. Lyons and D{\'e}sir{\'e} Collen and Kenneth D. Bloch and Stefan Janssens},
  journal={Circulation},
  year={2000},
  volume={102 23},
  pages={2880-5}
}
BACKGROUND Nitric oxide (NO) is a potent vasodilator with an important role in the regulation of pulmonary vascular tone. The effects of NO synthase (NOS) gene transfer on pulmonary vascular remodeling associated with hypoxic pulmonary hypertension are unknown. METHODS AND RESULTS We aerosolized 3 x 10(9) pfu of an adenoviral vector containing inducible NOS gene (AdNOS2), constitutive NOS3 gene (AdNOS3), or no transgene (AdRR5) into rat lungs. Exhaled NO levels, monitored with… CONTINUE READING