Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases.

@article{Koshkina2005AerosolGI,
  title={Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases.},
  author={Nadezhda V. Koshkina and Eugenie S Kleinerman},
  journal={International journal of cancer},
  year={2005},
  volume={116 3},
  pages={458-63}
}
Osteosacarcoma (OS) lung metastases are often resistant to chemotherapy. Most anticancer drugs are administered systemically. In many cases this is followed by dose-dependent toxicity, which may not allow the achievement of therapeutic levels in lungs to eradicate metastases. We determined the efficacy of gemcitabine (GCB) by administering it directly to the lungs via aerosol and studied the role of the Fas pathway in response to the therapy. We used 2 osteosarcoma lung metastases animal models… CONTINUE READING

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