Aerosol-derived airway morphometry and aerosol bolus dispersion in patients with lung fibrosis and lung emphysema.

@article{Brand1999AerosolderivedAM,
  title={Aerosol-derived airway morphometry and aerosol bolus dispersion in patients with lung fibrosis and lung emphysema.},
  author={Peter Brand and Martin Kohlh{\"a}ufl and T. Meyer and Titus Selzer and Joachim Prof Dr Heyder and Karl H{\"a}ussinger},
  journal={Chest},
  year={1999},
  volume={116 2},
  pages={
          543-8
        }
}
OBJECTIVE Patients with lung emphysema show increased aerosol-derived dimensions of peripheral airspaces and increased aerosol bolus dispersion (AD). To apply these tests in epidemiologic studies, the objective of this pilot study was to investigate whether morphometric changes caused by lung fibrosis can be distinguished from those caused by emphysema. DESIGN This study was designed as a cross-sectional study in which airspace dimensions and AD in patients with emphysema and in patients with… 
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Aerosol morphometry and aerosol bolus dispersion in patients with CT-determined combined pulmonary emphysema and lung fibrosis.
  • M. Kohlhäufl, P. Brand, +4 authors J. Heyder
  • Medicine
    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine
  • 2000
TLDR
The results of this study confirm that ADAM and ABD are powerful tools for identifying emphysema even in patients with superimposed pulmonary fibrosis.
Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease
TLDR
Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs, as expected, deposition increases for smaller particles and deeper inhalation.
Aerosol probes of emphysema progression in dogs treated with all trans retinoic acid--an exploratory study.
  • F. Rosenthal
  • Medicine
    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine
  • 2007
TLDR
The limited reversal of lung injury in this study contrasts with more pronounced treatment effects seen in previous studies with rats, as well as suggestions for improved experimental investigations of emphysema therapies.
PARTICLE CLEARANCE FROM THE AIRWAYS OF SUBJECTS WITH BRONCHIAL HYPERRESPONSIVENESS AND WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
TLDR
Long-term particle retention in the airways has to be taken into account in aerosol toxicology risk assessment and aerosol therapy dose evaluation.
Functional parameters of small airways can guide bronchodilator use in idiopathic pulmonary fibrosis
TLDR
FEV1/FVC cannot reflect the airflow limitation in IPF and is not a deciding factor in whether patients should receive bronchodilator treatment, while IOS parameters may be useful to guide bronchidilator therapy in patients with IPF coexisting with SAD.
Charting the human respiratory tract with airborne nanoparticles - evaluation of the Airspace Dimension Assessment technique.
TLDR
RAiDA has potential as an efficient new in vivo technique to assess individual lung properties and the information obtained by such measurements may be of value for lung diagnostics, especially for the distal lungs, which are challenging to examine directly by other means.
Physiology of the lung in idiopathic pulmonary fibrosis
TLDR
The profound alterations in lung mechanics, lung gas exchange, pulmonary gas exchange and airway physiology, as well as pulmonary haemodynamics related to IPF, are reviewed.
Comparison of the Measurement of Obstructive Pulmonary Disease Using Spirometry, Plethysmography and Aerosol Dispersion Techniques
TLDR
Aerosol Spirometry has been found to be a powerful tool in the differential diagnosis of chronic obstructive lung disease with higher sensitivity and specificity than conventional lung function parameters for assessing patients with chronic bronchitis, cystic fibrosis and asthma.
Do nanoparticles provide a new opportunity for diagnosis of distal airspace disease?
TLDR
The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature, and to have several advantages over other aerosol-based methods.
[Monte-Carlo-Model for the aerosol bolus dispersion in the human lung--part 1: theoretical model description and application].
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