Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases.

@article{Latimer2009AerosolDO,
  title={Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases.},
  author={Paul Latimer and Marla Menchaca and Rachel M. Snyder and Weiping Yu and Brian E. Gilbert and Bob G. Sanders and Kimberly Kline},
  journal={Experimental biology and medicine},
  year={2009},
  volume={234 10},
  pages={1244-52}
}
Paclitaxel is a chemotherapeutic agent used for the treatment of metastatic breast cancer. 2,5,7,8-Tetramethyl-2R-(4R, 8R-12-trimethyltridecyl) chroman-6-yloxyacetic acid (alpha-TEA) is an analog of vitamin E that inhibits primary tumor growth and the incidence of lymphatic and pulmonary metastases in preclinical animal models. Here, the efficacy of sequential treatment with paclitaxel and alpha-TEA was tested in the BALB/c syngeneic 66cl-4-GFP mammary cancer model. Both agents were formulated… CONTINUE READING

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