Aerosol delivery of chemotherapy in an orthotopic model of lung cancer.

@article{Gagnadoux2005AerosolDO,
  title={Aerosol delivery of chemotherapy in an orthotopic model of lung cancer.},
  author={Fr{\'e}d{\'e}ric Gagnadoux and Alain Le Pape and Etienne Lemari{\'e} and St{\'e}phanie Lerondel and Isabelle Valo and Val{\'e}rie Leblond and J-L Racineux and T. Kristen Urban},
  journal={The European respiratory journal},
  year={2005},
  volume={26 4},
  pages={
          657-61
        }
}
The aim of this study was to evaluate the effect on tumour growth of gemcitabine delivered by aerosol in an orthotopic model of lung carcinoma. Large cell carcinoma (NCI-H460) cells were implanted intrabronchially in 24 male BALB/c nude mice on day (d) 0. Aerosols were delivered once a week from d1 to d29 using an endotracheal sprayer. Altogether, 16 animals received gemcitabine at 8 (n=8) and 12 mg.kg-1 (n=8), and eight received a vehicle aerosol. Animals were sacrificed on d36 for… CONTINUE READING

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