Aerosol delivery during mechanical ventilation: from basic techniques to new devices.

@article{Dhand2008AerosolDD,
  title={Aerosol delivery during mechanical ventilation: from basic techniques to new devices.},
  author={Rajiv Dhand},
  journal={Journal of aerosol medicine and pulmonary drug delivery},
  year={2008},
  volume={21 1},
  pages={
          45-60
        }
}
  • R. Dhand
  • Published 8 March 2008
  • Engineering, Medicine
  • Journal of aerosol medicine and pulmonary drug delivery
Pressurized metered-dose inhalers (pMDIs) and nebulizers are routinely employed for aerosol delivery in mechanically ventilated patients. A significant proportion of the aerosol deposits in the ventilator circuit and artificial airway, thereby reducing the inhaled drug mass. Factors influencing aerosol delivery during mechanical ventilation differ from those in spontaneously breathing patients. The English language literature on aerosol delivery during mechanical ventilation was reviewed… 
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154 Citations

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The impact of various factors on aerosol delivery with pMDIs and nebulizers is reviewed, and the correlation between in-vitro estimates and in- vivo measurement of aerosol deposition in the lung is elucidated.
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Drug delivery using a VMN was significantly greater than that with a JN and pMDI for both standard and LTV ventilation, and the highest dose observed using the CombiHaler was observed.
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