Aerosol Route to Administer Teicoplanin in Mechanical Ventilation: In Vitro Study, Lung Deposition and Pharmacokinetic Analyses in Pigs

@inproceedings{GuillonAntoine2015AerosolRT,
  title={Aerosol Route to Administer Teicoplanin in Mechanical Ventilation: In Vitro Study, Lung Deposition and Pharmacokinetic Analyses in Pigs},
  author={GuillonAntoine and MercierEmmanuelle and LanottePhilippe and HaguenoerEve and DarrouzainFrançois and BarcC{\'e}line and SarradinPierre and Si-TaharMustapha and Heuz{\'e}-Vourc'hNathalie and DiotPatrice and VecellioLaurent},
  year={2015}
}
Abstract Backround: Glycopeptides given intravenously achieve low airway concentrations. Nebulization of teicoplanin may be an efficient way of delivering a high concentration of this antibiotic to the lung. This multistep study assessed the feasibility of teicoplanin nebulization during mechanical ventilation by evaluating: the stability of its antibiotic effect; epithelial tolerance; lung deposition and systemic absorption in ventilated pigs. Methods: Nebulized and non-nebulized teicoplanin… CONTINUE READING