Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

@article{Harrison1996AerosolII,
  title={Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes},
  author={Leonard C. Harrison and Majella Dempsey-Collier and David R. Kramer and Kazuma Takahashi},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={2167 - 2174}
}
Cellular immune hyporesponsiveness can be induced by the presentation of soluble protein antigens to mucosal surfaces. Most studies of mucosa-mediated tolerance have used the oral route of antigen delivery and few have examined autoantigens in natural models of autoimmune disease. Insulin is an autoantigen in humans and nonobese diabetic (NOD) mice with insulin-dependent diabetes mellitus (IDDM). When we administered insulin aerosol to NOD mice after the onset of subclinical disease, pancreatic… CONTINUE READING