Aerobic synthesis of vitamin B12: ring contraction and cobalt chelation.

@article{Heldt2005AerobicSO,
  title={Aerobic synthesis of vitamin B12: ring contraction and cobalt chelation.},
  author={D. Heldt and A. D. Lawrence and M. Lindenmeyer and E. Deery and P. Heathcote and S. Rigby and M. Warren},
  journal={Biochemical Society transactions},
  year={2005},
  volume={33 Pt 4},
  pages={
          815-9
        }
}
  • D. Heldt, A. D. Lawrence, +4 authors M. Warren
  • Published 2005
  • Chemistry, Medicine
  • Biochemical Society transactions
  • The aerobic biosynthetic pathway for vitamin B12 (cobalamin) biosynthesis is reviewed. Particular attention is focused on the ring contraction process, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed. Previous work had established that this chemically demanding step is facilitated by the action of a mono-oxygenase called CobG, which generates a hydroxy lactone intermediate. This mono-oxygenase contains both a non-haem iron and an Fe-S centre, but little… CONTINUE READING
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