Aerobic radiosensitization by SR 4233 in rodent and human cells: mechanistic and therapeutic implications.

@article{Zeman1991AerobicRB,
  title={Aerobic radiosensitization by SR 4233 in rodent and human cells: mechanistic and therapeutic implications.},
  author={Elaine M Zeman and Janice M. Y. Brown},
  journal={International journal of radiation biology},
  year={1991},
  volume={59 1},
  pages={117-31}
}
Mammalian cells surviving exposure to the bioreductive, cytotoxic agent SR 4233 under hypoxic conditions are sensitized to X-irradiation under aerobic conditions (and in the absence of drug). Fits of both the single-hit, multi-target and linear-quadratic expressions to survival data, as well as direct measurement of surviving fractions after a dose of 2 Gy… CONTINUE READING