Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia.

@article{Busk2008AerobicGI,
  title={Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia.},
  author={Morten Busk and Michael Robert Horsman and Paul E. G. Kristjansen and Albert J van der Kogel and Johan Bussink and Jens Overgaard},
  journal={International journal of cancer},
  year={2008},
  volume={122 12},
  pages={2726-34}
}
The hypoxia-responsiveness of the glycolytic machinery may allow pretreatment identification of hypoxic tumors from HIF-1 targets (e.g., Glut-1) or [18F]-fluorodeoxyglucose positron emission tomography but results have been mixed. We hypothesized that this discrepancy is an inevitable consequence of elevated aerobic glycolysis in tumors (Warburg effect) as energetics in predominantly glycolytic cells is little affected by hypoxia. Accordingly, we characterized glycolytic and mitochondrial ATP… CONTINUE READING

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