Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia

@article{Busk2008AerobicGI,
  title={Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia},
  author={M. Busk and M. Horsman and P. Kristjansen and A. J. van der Kogel and J. Bussink and J. Overgaard},
  journal={International Journal of Cancer},
  year={2008},
  volume={122}
}
The hypoxia‐responsiveness of the glycolytic machinery may allow pretreatment identification of hypoxic tumors from HIF‐1 targets (e.g., Glut‐1) or [18F]‐fluorodeoxyglucose positron emission tomography but results have been mixed. We hypothesized that this discrepancy is an inevitable consequence of elevated aerobic glycolysis in tumors (Warburg effect) as energetics in predominantly glycolytic cells is little affected by hypoxia. Accordingly, we characterized glycolytic and mitochondrial ATP… Expand
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