Aerobic fermentation of D-glucose by an evolved cytochrome oxidase-deficient Escherichia coli strain.

@article{Portnoy2008AerobicFO,
  title={Aerobic fermentation of D-glucose by an evolved cytochrome oxidase-deficient Escherichia coli strain.},
  author={Vasiliy Portnoy and Markus J. Herrg{\aa}rd and Bernhard O. Palsson},
  journal={Applied and environmental microbiology},
  year={2008},
  volume={74 24},
  pages={7561-9}
}
Fermentation of glucose to D-lactic acid under aerobic growth conditions by an evolved Escherichia coli mutant deficient in three terminal oxidases is reported in this work. Cytochrome oxidases (cydAB, cyoABCD, and cbdAB) were removed from the E. coli K12 MG1655 genome, resulting in the ECOM3 (E. coli cytochrome oxidase mutant) strain. Removal of cytochrome oxidases reduced the oxygen uptake rate of the knockout strain by nearly 85%. Moreover, the knockout strain was initially incapable of… CONTINUE READING

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