Aerobic expression of Vitreoscilla hemoglobin improves the growth performance of CHO-K1 cells.

@article{Jurez2017AerobicEO,
  title={Aerobic expression of Vitreoscilla hemoglobin improves the growth performance of CHO-K1 cells.},
  author={Mariana de Anda Ju{\'a}rez and Claudia Hayd{\'e}e Gonz{\'a}lez-De la Rosa and Elisa Mem{\'u}n and Juan-Carlos Sigala and Alvaro R. Lara},
  journal={Biotechnology journal},
  year={2017},
  volume={12 3}
}
Inefficient carbon metabolism is a relevant issue during the culture of mammalian cells for the production of biopharmaceuticals. Therefore, cell engineering strategies to improve the metabolic and growth performance of cell lines are needed. The expression of Vitreoscilla stercoraria hemoglobin (VHb) has been shown to significantly reduce overflow metabolism and improve the aerobic growth of bacteria. However, the effects of VHb on mammalian cells have been rarely studied. Here, the impact of… CONTINUE READING
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