Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

@inproceedings{Pigna2016AerobicEA,
  title={Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer},
  author={Eva Pigna and Emanuele Berardi and Paola Aulino and Emanuele Rizzuto and Sandra Zampieri and Susan Hamilton and Helmut Kern and Stefano Merigliano and Mario Gruppo and Mathias Mericskay and Zhenlin Li and Marco De Rocchi and Rossella Barone and Frank P. Macaluso and Valentina Di Felice and Sergio Adamo and Alessandra La Groia and Viviana Moresi},
  booktitle={Scientific reports},
  year={2016}
}
Recent studies have correlated physical activity with a better prognosis in cachectic patients, although the underlying mechanisms are not yet understood. In order to identify the pathways involved in the physical activity-mediated rescue of skeletal muscle mass and function, we investigated the effects of voluntary exercise on cachexia in colon carcinoma (C26)-bearing mice. Voluntary exercise prevented loss of muscle mass and function, ultimately increasing survival of C26-bearing mice. We… CONTINUE READING
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